4.2.6.6 Tandem Mass Spectroscopy
Mass spectroscopy is commonly referred to as a confirmatory technique since there is little doubt (error) in the identity of an analyte. To be even more certain of an analyte’s identify, two or even three, mass spectrometers can be used in series (the output of one MS is the input of another MS). Subsequent MS systems will select for a specific ion from the second MS and separate the masses in this peak for further identification. This technique allows for unit resolution or better in the first MS, subsequently separating the masses of a given peak in the second and third MS, and identified based on a three to four decimal place mass. You should be able to see the confirmatory nature of this technique. Mass filters of choice for use in tandem include magnetic sector, electrostatic, quadrupole, and ion trap systems.
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