4.2.2: Peak Resolution and Solute Zones
Peak resolution in capillary electrophoresis is dependent on many variables, including longitudinal diffusion, injection length, sample adsorption to capillary walls, electrodispersion, Joule heating, and detector cell size. The loss of peak resolution is often referred to as "zone broadening" in CE. As in other forms of chromatography, this results in reduced separation of compounds and increased difficulty in accurate peak integration.
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