4.3.2 Sample Purification

CE is attractive as a preparatory purification source because of its separatory strength. However, CE can only be used to purify small amounts of analyte, as the sample loading limit is low. However, small-volume fractions can be collected for sequencing DNA fragments, establishing biological activity of substances, and ascertaining the purity of a collected peak by reinjection.

Autosamplers can be programmed to run a sequence of samples so that, in the event that multiple runs must be made and fractions collected and combined, the instrument does not need to be attended for the entire period.