CHEMISTRY 320
Syllabus for Instrumental Methods of Analysis

Fall, 2008
Dr. Frank Dunnivant
Chemistry Department
Room 344/341
Whitman College
Walla Walla, WA 99362
dunnivfm@whitman.edu
www.whitman.edu/~dunnivfm
Office:  527-4751

Course goals:  This course explores the theory, principles of operation, and hands-on use of the basic instrumentation used in the chemical industry.  Whether or not you become an analytical chemist, you will find some form of chemical instrumentation being used in your field (including geology, biology, chemistry, and the medical industry).  As the formal textbook points out in the preface, there is no way all of the material in the text can be covered in one semester (possibly not even in two semesters).  My goal is that you come away from this course with a working knowledge of the theory and function of the commonly used instruments, and with the ability to figure out how to use other instruments that you may come across in your career.

This year the course material has radically changed from previously years.  You have three new textbooks that will be given out in class and one trade pamphlet.  The difficulty has gone up at least one order of magnitude.

Materials:

-Suggested Reference/Formal Text:  Skoog, Holler, & Nieman, Principals of Instrumental Analysis, Fifth Edition, Saunders College Publishing, 1998. (TWO COPIES ARE ON RESERVE IN PENROSE LIBRARY)

-Handed out Ebook:  Dunnivant and Ginsbach.  GC-MS and LC-MS:  A Basic Introduction

-Handed out Ebook:  Dunnivant and Ginsbach.  FAAS and ICP-MS:  A Basic Introduction

-PowerPoint-Based Class notes

-The Internet

-A scientific calculator (with statistical capabilities such as linear regression)

Class meeting times:

Lecture:            Tuesday, Wednesday, and Thursday at 10:00-11:00

361 Lab:            Tuesday from 1:00 – 4:00 or how ever long it takes

                                     Advanced organic lab section will be Thursday.

Grading Break-down:            Points

Exam 1                                    100            given probably 1/3 of the way through the sem.

Exam 2                                    100            given probably 2/3 of the way through the sem.

Presentation/Paper                 75            given during the last third of the sem.

Final (comprehensive)          100            given the last week of class/first of finals week

TOTAL                                    375

Exams will be taken out of class (on selected ~Fridays) so that we do not have a 1-hour time constraint.  Depending on the exam, I will allow 2 to 4 hours.  Exam dates will be determined at least one week in advance as we go through the semester.  ALL EXAMS ARE CLOSED BOOK, NOTES, INTERNET, AND FRIEND.

Grading:

92.0-100            A

90.0-91.9            A-

88.0-89.9            B+

82.0-87.9            B

80.0-81.9            B-

78.0-79.9            C+

72.0-77.9            C

70.0-71.9            C-

60-70                   D

<60                       F

CHEM 320 Schedule:

THIS IS THE FIRST TIME I HAVE TAUGHT 320 THIS WAY AND WITH THE NEW MATERIALS SO I WILL NOT ATTEMPT MAKE UP A FICTIONAL SCHEDULE.  HOWEVER THE LIST BELOW IS THE ORDER WE WILL COVER TOPICS.

Syl. and Overview

Good Laboratory Practices (Agilent Trade Pamphlet; Chapters 1, 2, 3, and 6)

Standards and Calibration (PowerPoint, Ebooks, Skoog pp 11-17)

Signal and Noise (PowerPoint; stats section of lab handout, Ebooks Chapters 1, Skoog Chapter 5)

Figures of Merit and Detection Limits (PowerPoint, stats section of lab handout and Ebooks Chapters1)

METAL ANALYSIS (FAAS, FAES, and ICP-MS Ebook)

Chemicals (Ebook)

Sample Preparation with respect to Metals (Ebook)

Optical and Electrical Components (Ebook and Skoog Chapter 7)

FAAS (Ebook and Skoog Chapter 9) & FAES (Ebook and Skoog Chapter 10)

ICP (Ebook and Skoog Chapter 10)

CHROMATOGRAPHY (GC, LC, and MS Ebook)

Chemicals (Ebook)

Sample Preparation with respect to Organics and Inorganics (Ebook)

Chromatography Theory (Ebook and Skoog Chapter 26)

HPLC (The HPLC Tutorial, Ebook and Skoog Chapter 28)

IC (The GC Tutorial, Ebook and Skoog Chapter 27)

ELECTROPHORESIS (Agilent Trade Pamphlet and Skoog Chapter 30)

MASS SPECTROMETRY (Previous mentioned both Ebooks)

Atomic versus Molecular Aspects of MS (Ebook)

Sample Introduction/Interfaces to Other Instruments (Ebooks and Skoog Ch 11 and Ch 20)

Ion Sources (Ebooks and Skoog Section 20B)

Mass Filters and Detectors (Ebooks and Skoog Section 11B for Atomic MS and Section 20C for molecular MS)

PRESENTATIONs/PAPERs

Depending on how much lecture/class time is left near the end of the semester each of you will give an in class 30-min to 1-hour presentation, or if no time is left you will write a paper, on an instrument or technique that we did not cover in class.  Topics will be assigned/granted on a first-come first-serve basis.  I must approve all topics.  I suggest using your textbook (Skoog) as a start in your topic selection process.  Some interesting topics are:

NMR (there are many possibilities here)

Imaging Scanning Electron Microscopy (SEM) and a variety of detectors

Atomic Force Microscopy (AFM)

Various Radiation Detection Instruments

Various Laser Spectroscopy Techniques/Instruments

Do not delay; start on this relatively early.

Official time for the final is Thursday, Dec. 14, 2:00-4:00 but I will allow you to take it during the last week of class or the first of final’s week.  (This will be comprehensive on the fairly “Big Picture” items that we covered in lecture and lab)