Metabolism

Cytochrome C ATP Synthase Acetyl CoA H+ gradient across the Mitochondria

Oxidative Phosphorylation



Main Points

  1. ETC produces a lot of ATP and regenerates FAD and NAD+
  2. 4 enzyme complexes are connected by 2 mobile electron carriers
  3. ATP is produced at complexes I, III, and IV
  4. The energy harnessed from electron flow is used to pump protons against the concentration gradient
  5. ATP synthase and electron transport are coupled by a proton gradient
  6. Protons are pumped out of the matrix and into the inner membrane space
  7. The inner membrane space has a net positive charge, and the matrix has a relative negative charge
  8. The free energy change at complex II is not great enough to pump protons across the membrane, and form ATP
  9. ATP translocase allows ATP to leave the mitochondria and ADP to enter