- Integrins are involved in focal adhesions. What is a focal adhesion an what is the role of integrins?
- What unique chemical characteristics do glycosaminoglycans possess, and why are they important? What is their relationship to proteoglycans?
- Name one predominant structural protein and one predominant adhesive protein, respectively, of the extracellular matrix.
- True or False: The basal lamina involves a type of collagen that is rope-like rather than net-like>
- Explain why apoptosis is critical for survival, yet can have drastic consequences if triggered inappropriately.
- State the choreographed series of events that takes place during apoptosis.
- State the function(s) / importance of the following in cell apoptosis: Bax, Bcl2.
- Thought question: Which would be worse, a cancer of the pluripotent stem cells in bone marrow, or a germ-cell mutation of a somatic cell type? (there is obviously no right answer, defend, define, and state your answers clearly and briefly)
- What distinguishes benign tumors from malignant ones? State the steps in cancer progression.
- How does the p53 gene product function in cell cycle control? What is its purpose?
- Name three general causes of neoplastic transformation.
- All of the causes in the previous question cause DNA damage, but not all DNA damage causes neoplastic transformation. Why?
- What are src, myc, and ras? How are they different from rbl, p53, and apc? Relate both to neoplastic transformation.
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