Papers (links point to pdf files)

• Juers, D.H.  Rob, B., Dugdale, M., Rahimzadeh, N., Giang, C., Lee, M., Matthews, B.W. & Huber, R.E. Direct and Indirect Roles of His-418 in Metal Binding and in the Activity of b-Galactosidase (E. coli). (2009) Accepted by Protein Science.
• Juers, D.H., Lovelace, J., Bellamy, H.D., Snell, E.H., Matthews, B.W. and Borgstahl, G.E.O. (2007) Changes to Crystals of E. coli b-galactosidase During Room-Temperature Low-Temperature Cycling and Their Relation to Cryo-Annealing. Acta Crystallographica D63, 1139-1153.
• Juers, DH , Kim J, Sieburth, S McN, and Matthews, BW. (2005) Structural Analysis of Silendiols as Transition-State-Analogue Inhibitors of the Benchmark Metalloprotease Thermolysin. Biochemistry 44: 16524-16528.
• Juers, DH and Matthews, BW. (2004) Cryo-cooling in macromolecular crystallography: advantages, disadvantages and optimization. Quarterly Reviews of Biophysics 37, 2 pp. 1-15.
• Juers, DH and Matthews, BW. (2004) The Role of Solvent Transport in Macromolecular Crystal Annealing. Acta Crystallographica, D60, 412-421.
• Juers, DH, Hakda, S, Matthews, B, Huber, G. (2003) Structural Basis for the Altered Activity of Gly794 Variants of E. coli b -galactosidase. Biochemistry 42: 13505-13511.
• Shoemaker, GK, Juers, DH, Coombs, JML, Matthews, BW and Craig, DB. (2003) Microheterogeneity in Enzyme Crystals. Biochemistry 42: 1707-1710.
• Juers DH, Heightman TD, Vasella A, McCarter, JD, Mackenzie L, Withers SG and Matthews BW.   (2001) A Structural View of the Action of E. coli (lac Z) b -Galactosidase. Biochemistry 40 : 14781-14794.
• Juers DH and Matthews BW. (2001) Reversible Lattice Repacking Illustrates the Temperature Dependence of Macromolecular Interactions. Journal of Molecular Biology 311 851-862.
• Juers DH , Jacobson RH, Wigley D, Zhang XJ, Huber RE, Tronrud DE and Matthews BW. (2000) High resolution refinement of b -galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for a -complementation. Protein Science 9 : 1685-1699.
• Juers DH , Huber RE and Matthews BW. (1999) Structural comparisons of TIM barrel proteins suggest functional and evolutionary relationships between b -galactosidase and other glycohydrolases. Protein Science 8 :122-136.
• Holland DR, Hausrath AC, Juers DH and Matthews BW. (1995) Structural analysis of zinc substitutions in the active site of thermolysin. Protein Science 4 : 1955-1965.

Dissertation: A Structural View of Beta-Galactosidase in Action (2000)

Talks and Presentations

• Rational Approaches to Crystal Cooling. Invited Lecture. CCP4 Study Weekend. Nottingham, UK. January, 2009.
• Rational Approaches to Cryocrystallography. Invited Lecture. Gordon Conference: Diffraction Methods in Structural Biology. Bates College, Lewiston, Maine. July, 2008.
• The Role of Cryoprotectants in the Successful Cooling of Protein Crystals. 10th Annual Meeting of the Northwest Section of the American Physical Society. Lewis & Clark College, Portland, OR. Invited Lecture. May, 2008.
• Physical Properties of Cryoprotective Solutions for Macromolecular Crystallography. Poster. Frontiers in Microrheology Workshop, UCLA, Los Angeles, CA, Feb 2008. Poster. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA, Feb 2008.
• Hysteresis in Cryo-Cooling Crystals of E. coli b-galactosidase and its Relations to Cryo-Annealing. Poster. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, March 2007. Poster. The 18th West Coast Protein Crystallography Workshop, Asilomar, CA, March 2007.
• Turning off a Carbon-Based Enzyme with a Silicon-Based Inhibitor. Poster. 50th Annual Meeting of the Biophysical Society, Salt Lake City, UT, Feb 2006.
• The Role of Cryoprotectants in Cryo-Cooling and Annealing. Poster. Annual Meeting of the Biophysical Society, Long Beach, CA, Feb 2005. Lecture. Northwest Crystallography Workshop, Seattle, WA, June 2004.
• The Role of Water Transport in Cryo-Annealing. Lecture. Annual Meeting of the American Crystallographic Association, Cincinnati, OH June 2003.
• The Role of Solvent Transport in Annealing. Lecture. 7 th Northwest Crystallography Workshop, Vancouver, BC, June 2002.
• Temperature Dependent Structural Changes in Frozen Crystals of beta-Galactosidase. Poster. 45th Annual Meeting of the Biophysical Society, Boston MA, Feb 2001. The 15th West Coast Protein Crystallography Workshop, Asilomar CA, Mar 2001.
• Reversible Changes in E. coli (lac Z) beta-Galactosidase Crystal Packing with Freezing. Lecture. 6th Northwest Crystallography Workshop, Eugene OR, July 2000.
• Structural Enzymology of E. coli beta-Galactosidase: The Role of a Ligand-Induced Switch in the Dual Activity of the Enzyme. Poster. The 14th West Coast Protein Crystallography Workshop, Asilomar CA, March 1999.
• High Resolution Structures of beta-Galactosidase Inhibitor Complexes. Poster. 12th Symposium of the Protein Society, San Diego CA, July 1998.
• Structural Studies Directed Towards the Mechanism of Action of beta-Galactosidase. Poster. 11th Symposium of the Protein Society, Boston MA, July 1997.
• Engineering by Nature and Why beta-Galactosidase is So Big. Lecture. 4th Northwest Crystallography Workshop, Eugene OR, June 1996.
• A Structural Basis for the Activity of beta-Galactosidase. Lecture. 12th West Coast Protein Crystallography Workshop, Asilomar CA, March 1995.