Students fulfilling their Senior
Research requirement under Professor Yancey's supervision work in the
broad area of Physiology:
Some students work off-campus over the summer or while studying abroad,
in physiology and medical laboratories and marine stations around the
world. They then work with Prof. Yancey on data analysis and thesis
RESEARCH: Some students work with Professor Yancey in his laboratory in the
summer and/or academic year. Projects are usually in his research area
of environmental stresses and adaptations, mainly in osmoregulation.
Most of the research in Prof. Yancey's laboratory focuses on organic osmolytes, small molecules that build up osmotic pressure inside cells to prevent
osmotic water loss, while at the same time not disturbing cell
Many osmolytes have other functions such as stabilizing proteins and
membranes, both in nature and in biotechnology and medicine. For
example, Dr. Yancey and his students and colleagues have found that
some osmolytes protect our kidneys from toxic wastes and others help
animals in the deep sea resist pressure inhibition of proteins. He has
also assisted medical researchers in using osmolytes to treat diseases
such as cystic fibrosis.
Yancey's Home Page for details.
RECENT EXAMPLES OF STUDENT THESES, COPYRIGHT PROTECTED:
Laxson*, C., N. E. Condon, J. C. Drazen, and P.H. Yancey (2011). Decreasing urea:methylamine ratios with depth in Chondrichthyes: A physiological depth limit? Physio. Biochem. Zool.84:494-505 online pre-publication
Moran*, Hiram. 2012. Analysis of Mercury in Deep-sea Grenadier
Gerringer*, M.E., Drazen, J.C., Summers, A.P., Linley, T.D., Jamieson, A.J., Yancey, P.H. (2017). Distribution, composition, and functions of gelatinous tissues in deep-sea fishes. Royal Soc. Open Sci. 4: 171063
Downing*, A.B., G.T. Wallace*, Paul H. Yancey (2018). Organic osmolytes of amphipods from littoral to hadal zones: Increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants. Deep-Sea Res. I, In Press, available online
|Research Area 1: Deep-Sea Osmolytes
and Other Marine Adaptations
participated in deep-sea and other marine research on the Wecoma, Thompson, and Atlantis with the Alvin submersible,
and lab/field research at Oregon State University, Mt.
Desert Island Biological Lab (Maine), Stanford's Hopkins Marine Station
Monterey Bay Aquarium Res. Inst. (Monterey/Moss Landing CA), Univ.
Hawai'i Manoa, Hawai'i Inst. Marine Biology, Yucatan Mexico reefs, Univ. St. Andrews
of Marine Projects:
to the high pressure of the deep benthos (1800-6400
m deep) (with J. Siebenaller, LSU, George Somero, Hopkins
Marine Stn., and Jeff Drazen, Univ.
Hawai'i); and PROJECT HADES (deep trench 6000-11,000m ecophysiology) with Dr. Drazen, Tim Shank (WHOI) and international collaborators.
- Unusual osmolytes in deep-sea
abyssal, hydrothermal-vent, and methane-seep animals
(with Ray Lee, WSU; Lisa Levin, Scripps)
- Coral osmolytes and coral larvae
cryopreservation (in Mary Hagedorn's lab, Hawai'i Inst. Marine Biology)
- Coral adaptations to low-salinity acidic waters of Yucatan (with Elizabeth Derse and Adina Payton, UCSC; and Mario Rebolledo-Vieyra and Laura Hernandez, Centro de Investigacion Cientifica de Yucatan)
- Osmolytes in salmon and endangered eels (with Gordon Cramb, U. St. Andrews, Scotland)--effects of pollutants
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|Research Area 2: MAMMALIAN
Some students have worked on the
mechanisms that allow kidney/brain cells to tolerate high levels of urea and/or
salt. This involves organic
osmolytes such as betaine, sorbitol,
glycerophosphorylcholine, and inositol.
Osmolytes as cellular protectants in mammalian development
Mammalian kidney and brain cell
osmoregulation, including the effects of i) dietary salt and protein,
ii) creatine loading by atheletes, iii) drugs to treat diabetes,
iv) analgesic drugs such as ibuprofen.
BETAPOWER betaine-based sports drink: effects on neurons
Normal kidney cells growing in culture; cells exposed to 1mM ibuprofen
(pictures from Karen Pantilat's 1996 research project
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regional, national or international meetings:
|ABOVE: Anna Downing '16 presents our work at the International Deep-Sea Biology Symposium, Aveiro, PORTUGAL -- Sept. 2016 (city in picture is Porto, where the banquet was held)
||ABOVE: Carrie Laxson '10 and Kristianne Chavez '10 present their deep-sea fish / coral research at the International Deep-Sea Biology Symposium, Reykjavik, ICELAND, Jun. 2010
Laxson*, C., N. E. Condon, J. C. Drazen, and P.H. Yancey (2011). Decreasing urea:methylamine ratios with depth in Chondrichthyes: A physiological depth limit? Physio. Biochem. Zool.84:494-505; see REFS below
|ABOVE: Mackenzie Gerringer in Wellington NZ, Dec. 2012. She presented our results (talk) at the 13th Deep-Sea Biology Symposium (where we also heard and talked to James Cameron about his record submarine dive).
ABOVE LEFT: Garth Brand and Athena Samerotte present their deep-sea fish research at the 13th Annual Murdock Undergraduate Science conference, Portland, 2004
Brand, G.L., R.V. Horak, N. LeBris, S.K. Goffredi, S.L. Carney, B. Govenar, P.H. Yancey (2007). Hypotaurine and thiotaurine as indicators of sulfide exposure in bivalves and vestimentiferans from hydrothermal vents and cold seeps. Mar. Ecol. 28: 208-18.
Samerotte, A.L., J.C. Drazen, G.L. Brand, B.A. Seibel, P.H. Yancey (2007). Contents of trimethylamine oxide correlate with depth within as well as among species of teleost fish: an analysis of causation. Phys. Zool. Biochem. 80: 197-208
MIDDLE ABOVE: Maria Aunon and Vanessa Walker present their work to government officials (NSF, Congress) at the 4th Annual Posters-on-the-Hill Conference, Washington DC, Apr. 2000
Yancey, P.H., A.L. Fyfe-Johnson, R.H. Kelly, V.P. Walker, M.T. Aunon (2001). Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts. J. Exp. Zool. 289:172
FAR RIGHT ABOVE: Jeanette Fiess, Jennifer Hom and Hilary Hudson present their work at the 2nd International Hydrothermal Vent Symposium, Brest, FRANCE, Oct. 2001
Fiess. J.C., J.R. Hom, H.A. Hudson, C. Kato, P.H. Yancey (2002). Phosphodiester amine, taurine and derivatives, and other osmolytes in vesicomyid bivalves: correlations with depth and symbiont metabolism. Cahiers Biol. Mar. 43: 337-340
LEFT: Matt Gillett presents his poster at the Society for Integrative and Comparative Biology, 1996 in Albuquerque; and studies high-pressure effects on a deep-sea fish enzyme at the Hopkins Marine Station
Gillett, M.B., J.R. Suko, F.O. Santoso, P.H. Yancey (1996). Elevated levels of trimethylamine oxide in muscles of deep-sea teleosts. Amer. Zool. 36: 35A (published as full paper in 1997; see REFS below
NEAR RIGHT: Noah Rosenberg presents a poster on our deep-sea research in Mt. Buller, AUSTRALIA, at the 6th Internat'l. Congress on Comparative Physiology and Biochemistry, Feb. 2003.
Rosenberg, N.B,, R.W. Lee, P.H. Yancey (2003). Adaptation to environmental stresses with osmolytes: possible roles for betaine, hypotaurine and thiotaurine in gastropods from hydrothermal vents. Comp. Biochem. Physiol. 134: S120 (Published as full paper in 2006; see REFS below)
FAR RIGHT-->Jenni Rohr presents her poster on diabetes-related work at the 33rd Internat'l Congress of Physiol. Sciences, St. Petersburg, RUSSIA
Rohr, J.M. and P.H. Yancey (1997). Effects of aldose reductase inhibitors, ascorbic acid and aminoguanidine on sorbitol contents in primary renal cultures. (Published as full paper in 1999; see REFS below
undergraduate co-authors* and former students**:
- Yancey, P.H., W.
Bement*, M. Maier* (1985). Temperature, pH and pressure effects on
lactate dehydrogenases of vertically migrating midwater fishes. Amer.
Zool. 25: 19A
- Yancey, P.H., R.
Lawrence-Berrey*, M. D. Douglas* (1989). Adaptations in mesopelagic
fishes. I. Buoyant glycosaminoglycan layers in species without diel
vertical migrations. Mar. Biol. 103: 453-459
- Yancey, P.H., J.
Ruble*, J.D. Valentich (1991). Effect of chloride secretagogues on
cyclic AMP formation in cultured shark (Squalus acanthias) rectal gland epithelial cells.
Bull. Mt. Des. I. Biol. Lab.13: 51-52
- Yancey, P.H., T.
Kulongoski*, M.D. Usibelli*, R. Lawrence-Berrey*, A. Pedersen* (1992).
Adaptations in mesopelagic fishes. II. Protein contents of various
muscles and actomyosin contents and structure of swimming muscle. Comp.
- Gillett*, M.B.,
J.R. Suko*, F.O. Santoso*, P.H. Yancey (1997). Elevated levels of
trimethylamine oxide in muscles of deep-sea gadiform teleosts: a
high-pressure adaptation? J.
- Kelly*, R.H., P.H.
Yancey (1999). High levels of trimethylamine oxide correlating with
depth in deep-sea teleost fishes, skates, and decapod crustaceans. Biol.
- Yancey, P.H., R.H.
Kelly*, A.L. Fyfe-Johnson*, M.T. Aunon*, V.P. Walker*, J. F.
Siebenaller (2000). Effects of osmolytes of deep-sea animals on enzyme
function and stability under high hydrostatic pressure. In: Science
and Technology of High Pressure: Proceedings of AIRAPT-17; Manghnani, M.H., W.J. Nellis,
M.T. Nicol (eds). Universities Press, Hyderabad, India
- Yin, M., H.R.
Palmer, A.L. Fyfe-Johnson*, J.J. Bedford, R.A. Smith, P.H. Yancey
(2000). Hypotaurine, N-methyltaurine, taurine, and glycine betaine as
dominant osmolytes of vestimentiferan tubeworms from hydrothermal vents
and cold seeps. Physiol.
- Yancey, P.H., A.L.
Fyfe-Johnson*, R.H. Kelly*, V.P. Walker*, M.T. Aunon* (2001).
Trimethylamine oxide counteracts effects of hydrostatic pressure on
proteins of deep-sea teleosts. J.
- Yancey, P.H., W.
R. Blake*, J. Conley* (2002). Unusual organic osmolytes in deep-sea
animals: adaptations to hydrostatic pressure and other perturbants. Comp.
Biochem. Physiol. A,
133 (3): 667-676 (click on vol. 133)
- Yancey, P.H., W.
R. Blake*, J. Conley*, R.H. Kelly (2002). Nitrogenous solutes as
protein-stabilizing osmolytes: counteracting the destabilizing effects
of hydrostatic pressure in deep-sea fish. In: Nitrogen
Excretion in Fish (Proc. Internatl. Congr. Biol.
Fish), Wright, P.A. and D. MacKinlay (eds.).
- Fiess*. J.C., J.R.
Hom*, H.A. Hudson*, C. Kato, P.H. Yancey (2002). Phosphodiester amine,
taurine and derivatives, and other osmolytes in vesicomyid bivalves:
correlations with depth and symbiont metabolism. Cahiers
Biol. Mar. 43:
- Yancey, P.H., M.D.
Rhea*, D. Bailey, K. Kemp (2004). Trimethylamine oxide, betaine and
other osmolytes in deep-sea animals: depth trends and effects on
enzymes under hydrostatic pressure. Cell Molec. Biol. 50: 371-376
- Rosenberg*, N.K.,
R.W. Lee, P.H. Yancey (2006). High contents of hypotaurine and
thiotaurine in hydrothermal-vent gastropods without thiotrophic
Exp. Zool. 305A: 655-662.
- Brand*, G.L., R.V. Horak*,
N. LeBris, S.K. Goffredi, S.L. Carney, B. Govenar, P.H. Yancey (2007).
Hypotaurine and thiotaurine as indicators of sulfide exposure in
bivalves and vestimentiferans from hydrothermal vents and cold seeps. Mar. Ecol. 28:
- Samerotte*, A.L., J.C. Drazen, G.L. Brand*, B.A.
Seibel, P.H. Yancey (2007). Contents of trimethylamine oxide correlate
with depth within as well as among species of teleost fish: an analysis
Zool. Biochem. 80: 197-208
- Fiess, J.C., A. Kunkel-Patterson*, L. Mathias*, L.G. Riley,
P.H. Yancey, T. Hirano, E.G. Grau. (2007). Effect of environmental
salinity and temperature on osmoregulatory ability, organic osmolytes,
and plasma hormone profiles in the Mozambique tilapia (Oreochromis
mossambicus). Comp. Physiol. Biochem.
P.H., J. Ishikawa*, B. Meyer*, P. Girguis, R. Lee (2009). Hypotaurine
and thiotaurine in polychaetes without endosymbionts from hydrothermal
vents: correlation with sulfide exposure. J. Exp. Zool.
M., V.L. Carter, S. Ly*, R.A. Andrell*, P.H. Yancey, J.A. Leong, F.W.
Kleinhans (2010). Analysis of internal osmolality in developing coral larvae, Fungia
scutaria. Phys. Biochem. Zool. 83: 157-166
- Yancey, P.H., M. Heppenstall*, S. Ly*, R.M. Andrell*, R.D. Gates, V.L. Carter, M. Hagedorn (2010). Betaines and dimethylsulfoniopropionate (DMSP) as major osmolytes in Cnidaria with endosymbiotic dinoflagellates. Phys.
Biochem. Zool. 83: 167-173
- Laxson*, C., N. E. Condon, J. C. Drazen, and P.H. Yancey (2011). Decreasing urea:methylamine ratios with depth in Chondrichthyes: A physiological depth limit? Physio. Biochem. Zool.84:494-505 online pre-publication
- Kalujnaia, S., S. Gellatly,
N. Hazon, A. Villasenor*, P.H. Yancey and G. Cramb
(2013). Tissue distribution of inositol monophosphatase
(IMPA) isoforms in two euryhaline teleosts, the European
eel (Anguilla anguilla) and the Nile tilapia (Orechromis
niloticus); the effects of SW-acclimation on isoform
expression and inositol production. Amer.
- Yancey, P.H., M. Gerringer*, A.A. Rowden, J.C. Drazen, A. Jamieson (2014). Marine fish may be biochemically constrained from
inhabiting the deepest ocean depths. Proc. Natl. Acad. Sci. USA Mar. 3; see news story here.
- Hagedorn, M., V. Carter, N. Zuchowicz, M. Phillips, C. Penfield, B. Shamenek, E.A. Vallen, F.W. Kleinhans, K. Peterson*, M. White*, P.H. Yancey (2015). Trehalose is a chemical attractant in the establishment of coral symbiosis. PLoS ONE 10.1371/journal.pone.0117087
- Divino, J.N., M. Monette, S.D. McCormick, P.H. Yancey, K.G. Flannery*, M.A. Bell, F.A. von Hippel, and E.T. Schultz (2016). Osmoregulatory physiology and rapid evolution of salinity tolerance in a recently introduced lake population of Threespine Stickleback. Evol. Ecol. Res. 17:179-201.
- Linley, T., M. Gerringer**, P.H. Yancey, J.C. Drazen, C. Weinstock*, A. Jamieson (2016). Fishes of the hadal zone including new species, in situ observations and depth records of Liparidae. Deep-Sea Research I 114: 99-110.
- Mills S., Leduc D., Drazen J. C., Yancey P., Jamieson A. J., Clark M. R., Rowden A. A., Mayor D. J., Piertney S., Heyl T., Bartlett D., Bourque J., Cho W., Demopoulos A., Fryer P., Gerringer** M., Grammatopoulou E., Herrera S., Ichino M., Lecroq B., Linley T. D., Meyer K., Nunnally C., Ruhl H., Wallace* G., Young C. and Shank T. M. (2016). 10,000 m under the sea: an overview of the HADES expedition to Kermadec Trench. IN: B. Golder and A. Connell (Eds.) Proceedings of Kermadec Discoveries and Connections (pp 36-38). The Pew Charitable Trusts.
- Gerringer**, M.E., Drazen, J.C., Yancey, P.H. (2017). Metabolic enzyme activities of abyssal and hadal fishes: pressure effects and a re-evaluation of depth-related changes. Deep-Sea Res. I 125: 135-146
- Gerringer*, M.E., Drazen, J.C., Summers, A.P., Linley, T.D., Jamieson, A.J., Yancey, P.H. (2017). Distribution, composition, and functions of gelatinous tissues in deep-sea fishes. Royal Soc. Open Sci. 4: 171063
- Gleason, L.U., L.P. Miller, J. Winnikoff, G.N. Somero, P.H. Yancey, D. Bratz*, and W.W. Dowd. (2017). Thermal history and gape of individual Mytilus californianus correlate with oxidative damage and thermoprotective osmolytes. J. Exp. Biol. 220: 4292-4304. News feature: jeb.biologists.org/content/220/22/4081.2
- Downing*, A.B., G.T. Wallace*, Paul H. Yancey (2018). Organic osmolytes of amphipods from littoral to hadal zones: Increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants. Deep-Sea Res. I. In Press
- Yancey, P.H., R.G. Haner*, T. Freudenberger*
(1990). Effects of an aldose reductase inhibitor on osmotic effectors
in rat renal medulla. Amer. J. Physiol. 259: F733-F738
- Edmands*, S., P.H.
Yancey (1992). Effects on rat renal osmolytes of extended treatment
with an aldose reductase inhibitor. Comp. Biochem. Physiol. 103C: 499-502
- Peterson*, D.P., K
M. Murphy*, R. Ursino*, K. Streeter*, P.H. Yancey (1992). Effects of
dietary protein and salt on rat renal osmolytes: co-variation in urea
and GPC contents. Amer. J. Physiol. 263: F594-F600.
- Walsh*, L.P., P.H.
Yancey (1994). Hyperthermic and hypertonic shock induce HSP70
accumulation and thermotolerance but not osmotic tolerance in cultured
mammalian renal cells. The Physiologist 37: A98 (poster abstract)
- Edmands*, S.D.,
K.S. Hughs*, S. Lee*, S.D. Meyer*, E. Saari, P.H. Yancey (1995).
Time-dependent aspects of osmolyte changes in rat kidney, urine, blood
and lens with sorbinil and galactose feeding. Kidney Int. 48: 344-353
- Rohr*, J.M., S.
Truong*, T. Hong*, P.H. Yancey (1999). Effects of ascorbic acid,
aminoguanidine, sorbinil and zopolrestat on sorbitol and betaine
contents in cultured rat renal cells. Exp.
- Miller*, T., R.
Hanson*, P.H. Yancey (2000). Developmental changes in organic osmolytes
in prenatal and postnatal rat tissues. Comp.
125A:45-56 (click on vol. 125).
- Knight, L. S., Q. Piibe*, C. Perkins*, I. Lambie*, and P.H. Yancey (2017). Betaine in the brain: characterization of betaine uptake, its influence on other osmolytes and its potential role in neuroprotection from osmotic stress. Neurochem. Res. 12: 3490-3503.
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